BUPRENORPHINE-SUPPLEMENTED ANAESTHESIA

Thiopentone supplemented anaesthesia for neurosurgery.

A technique of anaesthesia for intracranial surgery involving the use of a thiopentone drip as a supplement to nitrous oxide and oxygen was used in 166 patients who were curarized and artificially ventilated. Maintenance of immobility and unconsciousness during the operation was satisfactory. The degree of recovery at the end of operation was acceptable in that nearly 90 per cent were awake and...

Comparison of tramadol and buprenorphine analgesia for continuous intravenous propofol anaesthesia in dogs undergoing dental prophylaxis

The objective of this study was to compare, in client-owned patients, the analgesic effects of the centrally acting analgesics tramadol and buprenorphine in continuous intravenous anaesthesia (TIVA) with propofol. The study included forty dogs aged two to seven years and weighing 6–27 kg undergoing prophylactic dental treatment. The animals were classified into ASA (American Society of Anaesthe...

Respiratory depression following administration of low dose buprenorphine as postoperative analgesic after fentanyl balanced anaesthesia.

Opioids are among the most ancient and widely used drugs in anaesthesiology. The pharmacology of opioid analgesics and their receptors is a complex and not fully understood matter; even more complex are the interactions between different classes of opioids at both molecular and clinical levels. We want to report here a clinical observation to emphasize the importance of the theoretical basis of...

Buprenorphine.

Buprenorphine

In the crystal structure of a semi-synthetic opioid drug buprenorphine, C29H41NO4 {systematic name: (2S)-2-[(5R,6R,7R,14S)-9α-cyclo-propyl-methyl-3-hy-droxy-6-meth-oxy-4,5-ep-oxy-6,14-ethano-morphinan-7-yl]-3,3-di-methyl-butan-2-ol}, the cyclo-propyl-methyl group is disordered over two sites with an occupancy factor of 0.611 (3) for the major component. One of the hy-droxy groups is involved in...